Extracellular Vesicles and Renal Endothelial Cells

This review focuses on typical hemolytic uremic syndrome (HUS), a life-threatening sequela of human infections caused, particularly in children, by Shiga toxin–producing Escherichia coli strains. Thrombotic microangiopathy the brain and kidney is end point toxin action, resulting hallmarks HUS (ie, thrombocytopenia, anemia, acute renal failure). A growing body evidence points to role extracellular vesicles released blood patients toxin-challenged circulating cells (monocytes, neutrophils, erythrocytes) platelets, as key factor pathogenesis HUS. provides i) an updated description E. infections; ii) analysis cell–derived vesicles, their parent cells, triggering factors HUS; iii) model explaining why toxin–containing dock preferentially endothelia target organs. The study given disease outlines describes chain events involved development pathologic condition. In case infectious diseases, identification microbial pathogenic host-pathogen interactions clarifies mechanisms underlying pathogenetic process. many cases, however, particular consequence complex several virulence factors, whereby illness may not occur if one these removed or interplay impaired. condition caused bacteria known (STEC), which release potent exotoxin, named toxins (Stx).1Detzner J. Pohlentz G. Muthing Valid presumption toxin-mediated damage developing erythrocytes EHEC-associated syndrome.Toxins (Basel). 2020; 12: 373Crossref Scopus (5) Google Scholar,2Tarr P.I. Gordon C.A. Chandler W.L. 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Matsuguchi Masuda Kikuchi Musikacharoen Yoshikai Cutting edge: naturally soluble form mouse